Mechanism of transcutaneous immune responses in skin and draining lymph nodes

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860115
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Osaka University
• Principal Investigator: Hirobe Sachiko 大阪大学, 薬学研究科(研究院), 助教 (70644582)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 経皮ワクチン / 皮膚免疫 / マイクロニードル

Outline of Final Research Achievements

In this study, we tried to clear the mechanism of immune responses by transcutaneous vaccination, whose efficacy is stronger than that of conventional injectable vaccination. We compared immune responses by transcutaneous vaccination using two type of transcutaneous vaccine devices (hydrogel patch and microneedle patch) to that by injectable vaccination (subcutaneously and intradermally). The differences between transcutaneous vaccination and injectable vaccination were recognized in mRNA expression in skin, population of dendritic cells in draining lymph nodes, and activation of T or B cells. Those results indicated that these differences contributed to high antibody production by transcutaneous vaccination.

Free Research Field

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