2014 Fiscal Year Final Research Report
Ophthalmic formulation of solid nanoparticles permits the retinal therapy, and lead to the therapy in the glaucoma patient
| Project/Area Number |
25860129
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | ナノ粒子 / シロスタゾール / 眼後部治療 / 網膜 / 緑内障 / 角膜透過 / 眼圧 / DDS |
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| Outline of Final Research Achievements |
We attempted to establish a new method for preparing drug solid nanoparticles, and succeeded in preparing a high quality dispersion containing cilostazol (CLZ) nanoparticles. In addition, the instillation of the ophthalmic dispersions containing CLZ nanoparticles suppresses retinal vasoconstriction in endothelin-1-injected rats. It is possible that an ocular drug delivery system using drug nanoparticles may expand their usage as therapy in the glaucoma patient.
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| Free Research Field |
医歯薬学
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