Role of membrane traffic in the development and maintenance of skeletal muscle.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860138
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Gunma University
• Principal Investigator: Tajika Yuki 群馬大学, 医学(系)研究科(研究院), 講師 (90400738)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨格筋 / SNARE蛋白質

Outline of Final Research Achievements

Skeletal muscle cells have long, cylindrical shape. Development of the skeletal muscle cells is thought to be regulated by the intracellular membrane traffic, however, the membrane trafficking system in skeletal muscle cells is not fully understood. To gain an insight, I generated the knock-out mice lacking a member of SNARE proteins. The heterozygote and homozygote mice were often died around the birth. Skeletal muscles in mice lacking the molecule of interest seem to be normal. I found morphological defect in respiratory system and nervous system. These findings suggest that a member of SNARE proteins function in the development of respiratory system and nervous system, but not in skeletal muscles.

Free Research Field

骨格筋の細胞生物学