2014 Fiscal Year Final Research Report
The analysis of the mechanism for morphological changes and functions in rat anterior pituitary cells by use of proteoglycans.
| Project/Area Number |
25860148
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 下垂体前葉 / 濾胞星状細胞 / S100βタンパク陽性細胞 / プロテオグリカン / 樹状細胞 / 細胞外マトリクス |
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| Outline of Final Research Achievements |
S100β protein-expressing cells (folliculo-stellate cells) have a star-like appearance and are interconnected by cytoplasmic processes in the anterior pituitary gland. We reported that folliculo-stellate cells produce proteoglycans, which are components of the extracellular matrix (ECM) and are composed of a specific core protein substituted with covalently linked glycosaminoglycan chains. They also appear to possess multifunctional properties. Considering their pleiotropic features, folliculo-stellate cells are assumed to be of a heterogenous. They were classified into subtypes such as stem cells, progenitor cells, epithelial cells, astrocytes and dendritic cells. In the present study, we found a method for isolating dendritic cell-like folliculo-stellate cells by use of adherent activity to ECM and revealed their function. These findings bring a novel insight to the understanding of the mechanism of cellular arrangement in the anterior pituitary gland.
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| Free Research Field |
医歯薬学
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