Physioligical significance of Kv1.3-channels expressed in developing and regenerating kidneys

2016 Fiscal Year Final Research Report

• Project/Area Number: 25860155
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Tohoku University
• Principal Investigator: KAZAMA ITSURO 東北大学, 医学系研究科, 准教授 (60593978)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 発生腎 / 再生腎 / 慢性腎不全 / Kv1.3

Outline of Final Research Achievements

Thymus-derived lymphocytes (T lymphocytes) or megakaryocytes predominantly express delayed rectifier K+-channels (Kv1.3) in their plasma membranes. The channels are also expressed in various types of cancer cells and are responsible for the proliferation or differentiation of cells. To reveal the involvement of the Kv1.3-channels in the development of embryonic kidneys, we examined the effects of a selective Kv1.3-channel inhibitor, margatoxin, on the growth of the isolated kidney rudiments. Since margatoxin worked to preserve the metanephric mesenchyme in the developing kidneys, Kv1.3-channels expressed in embryonic kidneys were thought to be involved in the differentiation of the metanephric mesenchyme.

Free Research Field

生理学一般