Ubiquitin-independent endosomal sorting of cytokine receptors

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860161
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Shinshu University
• Principal Investigator: AMANO Yuji 信州大学, 学術研究院医学系, 助教 (50624681)
• Research Collaborator: TAKESHITA Toshikazu 信州大学, 学術研究院医学系, 教授 (60212023) ; KOJIMA Katsuhiko 信州大学, 学術研究院医学系, 講師 (80345743) ; YOSHINO Kazuhisa 信州大学, 学術研究院医学系, 助教 (40551859)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 小胞輸送

Outline of Final Research Achievements

We had reported that ubiquitin-independent endosomal sorting mechanism of interleukin-2 receptor β (IL-2Rβ) and interleukin-4 receptor α (IL-4Rα）. Hrs, which is also involved in an ubiquitin-dependent endosomal sorting, binds the hydrophobic amino acids clusters of the receptors and sorts the receptors into endosomes. Here, we elucidated that the hydrophobic amino acids clusters act as endosomal sorting signal and suggest Hrs controls endosomal sorting by novel manner.

Free Research Field

細胞生物学