Defection of signaling of adenosine receptors in Delayed sleep phase syndrome (DSPS)

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860176
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Tohoku University
• Principal Investigator: SUZUKI Tokiko 東北大学, 薬学研究科(研究院), 助教 (10415531)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: アデノシン / DSPS

Outline of Final Research Achievements

Delayed sleep phase syndrome (DSPS) is one of the sleep disorder which shows delay of circadian phase to have difficulty in social life. After sleep deprivation of 24 hours, patient of this disorder cannot enter recovery sleep which healthy individuals have immediately after relief of sleep deprivation. It is reported that accumulation of adenosine in basal forebrain is involved in regulation of recovery sleep. Accordingly, I examined the possibility of involvement of adenosinergic signaling in defect of sleep regulation in DSPS using model mice. As a result, I obtained result which suggests alteration of expression of adenosine receptor between DSPS model mice and wild-type mice in basal forebrain.

Free Research Field

時間薬理学