Circadian rhythm disruption in human cancers

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860179
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Yasuhiro Umemura 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40612734)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 体内時計 / がん / 細胞分化

Outline of Final Research Achievements

To elucidate the correlation between circadian clock development and differentiation stage of cancer cells, the circadian clock in the several human cancer cell lines were investigated. The circadian clock rhythm of these human cancer cell lines was not detected. However, the clock gene set in these cell lines was expressed. Next, the model of cancer development cell lines by myc overexpression using mouse embryonic stem cells (ESCs) was established. The in vitro differentiated ES cells during the induction of myc showed no circadian rhythm oscillation. The global gene expression analysis by RNA-seq identified the gene network inhibiting clock formation.

Free Research Field

体内時計