2014 Fiscal Year Final Research Report
The involvement of ATP/adenosine in the therapeutic hypothermia for brain ischemia
| Project/Area Number |
25860193
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | アデノシン / 脳虚血 / ATP / 低体温療法 / 海馬 |
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| Outline of Final Research Achievements |
The therapeutic hypothermia for acute stroke might play an important role in neuroprotection, however, the key mechanism of this therapy is still undetermined. We hypothesize that hypothermia enhances ATP/adenosine-mediated neuroprotection against ischemia. To elucidate this hypothesis, we recorded filed EPSPs from stratum radiatum of area CA1 in the acute hippocampal slices of adult mice and oxygen-glucose deprivation (the model of ischemia in vitro) was exposed while changing temperatures. The results suggest that hypothermia has protective effect on ischemia-induced loss of synaptic activity through activation of adenosine receptors.
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| Free Research Field |
中枢神経薬理
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