Regulation of NF-kappaB signalling by MARCH9

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860207
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry
• Research Institution: Gunma University
• Principal Investigator: GOTO EIJI 群馬大学, 生体調節研究所, 助教 (40435649)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ユビキチン / NF-κB

Outline of Final Research Achievements

Nuclear factor-κB (NF-κB) is activated by various stimuli, including cellular stresses, UV irradiation and cytokines. NF-κB is essential for immune and inflammatory responses, and abnormal NF-κB signalling is implicated in multiple diseases. In the present study, we identified MARCH9 as a new candidate protein for regulation of NF-κB signalling. Further detailed study of MARCH9 will provide clues as to the underlying cause of multiple NF-κB-related diseases.

Free Research Field

分子細胞生物学