Analysis of the role of inflammation on gastric cancer formation using a mouse model

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860230
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Kanazawa Medical University (2014); The University of Tokyo (2013)
• Principal Investigator: TAKEDA Haruna 金沢医科大学, 医学部, 助教 (80647975)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: マウスモデル / がん

Outline of Final Research Achievements

H. Pylori infection causes chronic inflammation and correlates to the high incidence of gastric cancers. To analyze the effect of inflammation on gastric cancer formation, Helicobacter Felis was infected to the mouse stomach. Thirty weeks post infection, mouse stomachs were analyzed histopathologically. However, considerable individual variation in the degree of the inflammation was observed, showing to be difficult to reproduce the results, therefore I finished this experiments.
Previously I performed SB transposon based insertional mutagenesis screening in mice to identify colorectal cancer (CRC) genes, I then analyzed these results. From this screen, we could identify 1333 CRC genes, and 6 genes involving the tumor progression. These 6 genes include Rnf43, which is a negative regulator of Wnt and often mutated in human CRC.

Free Research Field

腫瘍学