Identification of Mouse Mesenteric Adipocyte Progenitor Cells and Development of anti-metabolic syndrome drugs

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860237
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Osaka University
• Principal Investigator: MIYATA Yugo 大阪大学, 医学(系)研究科(研究院), 特任研究員 (70623453)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: メタボリックシンドローム

Outline of Final Research Achievements

White adipose tissues (WATs) are classified into visceral and subcutaneous WAT and they have distinct metabolic and biological properties. Many reports have suggested that there are depot specific preadipocytes in each WAT. However, visceral preadipocytes has not been identified until now. In the present study, we aimed to identify preadipocytes from mouse visceral and subcutaneous WATs, and to develop new anti-metabolic syndrome drugs by using mature visceral adipocytes from visceral preadipocytes.
Through in vitro screening and in vivo implantation experiments, visceral preadipocytes were identified. Furthermore, we confirmed that differentiated adipocytes obtained from mesenteric and subcutaneous preadipocytes maintained each characteristic phenotype in vitro as reported in each WAT in vivo. We also developed a simple method for culturing those preadipocytes.

Free Research Field

分生物学