Study on the brain-specific ncRNA related to mental disorder

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860239
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Hiroshima University
• Principal Investigator: FURUMAI Ryohei 広島大学, 医歯薬保健学研究院, 特任助教 (30450414)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ノンコーディングRNA

Outline of Final Research Achievements

Brain-specific non-coding RNA (ncRNA) responsible for the pathogenesis of Prader-Willie syndrome, a rare developmental/mental disorder, was knock-downed in the primary cultured neurons obtained from wild type mouse brain. Then we compared the global transcriptome between control and knock-downed neurons by next-generation sequencer. As a result, we found that the expressions of several genes and miRNAs were significantly changed in knock-downed neurons. Our finding suggested that transcriptional changes in these genes/miRNAs in knock-downed neurons could be related to the etiology of Prader-Willie syndrome.

Free Research Field

分子生物学