Analysis of mature B cell lymphomagenes by mutated epigenetic factors

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860245
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Keio University
• Principal Investigator: SUGIHARA Eiji 慶應義塾大学, 医学部, 特任助教 (50464996)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: リンパ腫 / エピジェネィクス / c-Myc / Ezh2 / MEF2B

Outline of Final Research Achievements

It has been suggested that deregulation of gene transcription by epigenetic abnormality contributes to tumorigenesis. In this study, we focused on the histone modification-regulated factors Ezh2 and MEF2B whose gene mutations have been often reported, and studied their roles in mature B cell lymphomagenesis. Although mutated Ezh2 enhanced the tri-methylation of histone H3K27, exogenously expression of mutated Ezh2 in germinal center B cells did not induce lymphoma in transplanted mice. MEF2B also showed similar results. On the other hands, c-Myc, frequently overexpressed in lymphoma, could directly induce mature B cell lymphoma. Therefore, mutated histone modification-regulated factors are not direct drivers in lymphomagenesis but probably contribute to the promotion of lymphoma.

Free Research Field

分子腫瘍学