2015 Fiscal Year Final Research Report
Effects of LXR on innate immune responses in hepatic mononuclear cells
| Project/Area Number |
25860248
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | liver X receptor / 炎症 / 肝臓 / マクロファージ / NKT細胞 |
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| Outline of Final Research Achievements |
The liver X receptor (LXR) plays a role in regulation of cholesterol homeostasis. LXR is also involved in inflammation and immunity. However, a role of LXR in liver immune cells remains unclear. In this study, we investigated effects of LXR on distribution and function of mouse hepatic mononuclear cells. As compared with wild-type mice, the total cell number and the proportion of bone marrow derived macrophages were increased in the liver of LXR-deficient mice. Proinflammatory cytokine production induced by lipopolysaccaride was also enhanced in LXR-deficient mice. On the other hand, the proportion of hepatic natural killer T cells was decreased and their cytokine production capacity was defected in LXR-deficient mice. We showed that LXR may be an important mediator that regulates hepatic immune cell population and cytokine production.
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| Free Research Field |
生化学
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