2015 Fiscal Year Final Research Report
Analysis of the regulatory mechanism of the human histone methyltransferase SETDB1
| Project/Area Number |
25860253
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
Tachibana Keisuke 大阪大学, 薬学研究科(研究院), 招へい教員 (30432446)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ヒストンメチル化酵素 / SETDB1 / 細胞内局在 |
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| Outline of Final Research Achievements |
SETDB1 is a histone methyltransferase that methylates lysine 9 on histone H3. We found that a post-translational modification of hSETDB1 is important to regulate its methyltransferase activity. Moreover, we identified the regions necessary for interaction between hSETDB1 and hMCAF1. Finally, we showed that nuclear hSETDB1 might be degraded by the proteasome and exported to the cytosol. Theses findings will be useful for regulating hSETDB1 function.
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| Free Research Field |
病態医化学
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