2014 Fiscal Year Final Research Report
The roles of EBV-encoded microRNAs in the regulation of apoptosis and carcinogenesis
| Project/Area Number |
25860262
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | Epstein-Barr ウイルス / アポトーシス / 胃癌 |
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| Outline of Final Research Achievements |
To clarify the roles of EBV-encoded microRNAs in gastric carcinogenesis, surgically resected gastric carcinoma tissues and gastric carcinoma cell lines were analyzed. Comprehensive expression profiling of EBV-encoded microRNAs revealed several EBV microRNAs were highly expressed. Genes which are potentially targeted by these microRNAs were identified by in silico analysis. In vitro study showed ebv-miR-BART4-5p inhibits Bid, one of the apoptosis activators, which leads to resistance to apoptosis.
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| Free Research Field |
人体病理学
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