2015 Fiscal Year Final Research Report
Regulation of macrophage in adipose tissue by CXCL14 and its receptor.
| Project/Area Number |
25860304
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
TANEGASHIMA Kosuke 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主任研究員 (20507678)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | CXCL14 / 炎症 |
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| Outline of Final Research Achievements |
Disruption of CXCL14 in mice ameliorates obesity-induced chronic inflammation. We aimed to investigate how CXCL14 activates inflammatory signaling at the molecular level. We found that CXCL14 specifically bound to a TLR9-ligand, CpG DNA and acted as a cofactor. CXCL14/CpG DNA complex was efficiently incorporated into dendritic cells and macrophages and induced robust expression of Th1 type inflammatory cytokines. These results suggested that CXCL14 plays a new role for the activation of the innate immune pathway.
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| Free Research Field |
分子生物学
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