Pathogenic analysis of S. aureus isolated from Staphylococcal Scaled skin syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860321
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Hiroshima University
• Principal Investigator: HISATSUNE Junzo 広島大学, 医歯薬保健学研究院, 助教 (40513180)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 細菌 / ゲノム / タンパク質 / 微生物

Outline of Final Research Achievements

On the investigation A), we found that A domain of Skip deletion mutant strain was not digested by human serum and human plasmin. And then, we found that cutting site of Skip have about N terminus 20 amino acid in A domain of Skip.On the investigation B), highly expressing Skip strain lacked 6-nucleotides in internecine region of arT and sarU. We found that global regulator MgrA binds to the region containing 6-nucleotides and lack of the short stretch prevents the binding of the MgrA, hence expression of SarT/SarU induces expression of Skip. In this study, we uncovered one of the reason why the strains causing SSSS shows high expression of Skip.

Free Research Field

細菌ゲノム