2016 Fiscal Year Final Research Report
The examination of mechanism of specific rejection
| Project/Area Number |
25860370
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Research Collaborator |
Uchiyama Kazuhisa (80232867)
Yoshida Ryotaro
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 移植免疫 / 主要組織適合性抗原 |
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| Outline of Final Research Achievements |
Dd and Kd genes are equivalent as allogeneic MHC class I genes and that
C57BL/6 (DbKb) mice reject Dd-, Kd-, or DdKd-transgened skin or tumor cells in a transgene numberdependent, gene expression rate-independent manner.
Using our new MHC class I transgenic strains of mice, we could not define whether allografts are controlled by alloreactive cytotoxic macrophages via MMR1 and MMR2 receptors or by R15 and R12.
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| Free Research Field |
移植免疫
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