2014 Fiscal Year Final Research Report
Effects of Runx1-associated lncRNA on asthma pathogenesis
Project/Area Number |
25860374
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
SEO WOOSEOK 独立行政法人理化学研究所, 統合生命医科学研究センター, 国際特別研究員 (40574116)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Keywords | CD4T細胞 / Runx1転写因子 / long non-coding RNA / ヒト喘息疾患発症 |
Outline of Final Research Achievements |
Runx1 knockout mice spontaneously develop lung inflammation resembling human asthma; however, its mechanism is not known yet. Examination of Runx1 locus shows a long non-coding RNA (lncRNA) located near Runx1 gene. This novel lncRNA shows a very low expression, but it is restricted to helper T lymphocytes. Knockdown of Runx1-lncRNA shows differential expressions of Runx1 target genes. Also, Runx1-lncRNA knockout mouse develops lung pathologies similar to Runx1 knockout mice. Therefore, we conclude that Runx1-lncRNA is functionally related to Runx1 protein.
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Free Research Field |
医歯薬学
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