Effects of Runx1-associated lncRNA on asthma pathogenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860374
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: SEO WOOSEOK 独立行政法人理化学研究所, 統合生命医科学研究センター, 国際特別研究員 (40574116)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: CD4T細胞 / Runx1転写因子 / long non-coding RNA / ヒト喘息疾患発症

Outline of Final Research Achievements

Runx1 knockout mice spontaneously develop lung inflammation resembling human asthma; however, its mechanism is not known yet. Examination of Runx1 locus shows a long non-coding RNA (lncRNA) located near Runx1 gene. This novel lncRNA shows a very low expression, but it is restricted to helper T lymphocytes. Knockdown of Runx1-lncRNA shows differential expressions of Runx1 target genes. Also, Runx1-lncRNA knockout mouse develops lung pathologies similar to Runx1 knockout mice. Therefore, we conclude that Runx1-lncRNA is functionally related to Runx1 protein.

Free Research Field

医歯薬学