Development of new vulnerable plaque specific arteriosclerosis diagnostic method using FRET method

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860393
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Okayama University
• Principal Investigator: Ogawa Hiroko 岡山大学, 大学病院, 助教 (70423283)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 動脈硬化 / イメージング

Outline of Final Research Achievements

In the present study, we aimed to develop a method for detecting the more sensitive unstable plaque. We consider to use the fact that extracellular matrix degrading enzymes is expressed in unstable plaques. Labeled with fluorescence protein as a substrate, it was planning to encapsulated in liposomes. Takes time to create the recombinant protein, it took time than expected. In addition, the labeling of the fluorescence of the recombinant protein was also created, resulting in a delay in the research plan. The study period was completed, but continue, is expected to continue the research.

Free Research Field

動脈硬化