2015 Fiscal Year Final Research Report
Investigation of progression in renal cell carcinoma by functional analysis of CXCR3: exploration of novel tumor markers
| Project/Area Number |
25860401
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 腎細胞癌 / 転移 / バイオマーカー / CXCR3 |
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| Outline of Final Research Achievements |
This study clarified that the expression of CXCR3A and CXCR3B play an important role in progression and metastasis in renal cell carcinoma (RCC). The ratio of CXCR3A/CXCR3B was significantly higher in patients with metastatic RCC at the time of surgery. The RCC cell line, 786-O, which has a higher ratio of CXCR3A/CXCR3B significantly increased in migration and invasion function by addition of the ligand CXCL10.
Furthermore, the ligands, CXCL9 and CXCL10, might be able to reflect the condition of a disease in metastatic RCC patients who took sunitinib. CXCL9 and CXCL10 show the possibility as a new tumor biomarker, when the patients with metastatic RCC receive the molecular targeted therapy.
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| Free Research Field |
泌尿器科学
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