2014 Fiscal Year Final Research Report
Dysfunction of apolipoprotein A-I reabsorption in diabetic proximal tubule
| Project/Area Number |
25860414
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 糖尿病性腎症 / キュビリン / Apo A-I |
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| Outline of Final Research Achievements |
Effects of nonenzymatic glycation on apo A-I reabsorption via cubilin in proximal tubule were evaluated. It was clarified by using cubilin peptide-coated ELISA that glycation impaired the binding properties of apo A-I to cubilin. Additionally the binding capacity and the uptake of glycated apo A-I to human proximal tubular cell diminished. Our results suggested that nonenzymatic glycation diminished the binding capacity of apo A-I to cubilin, may result in the decrease of apo A-I reabsorption by proximal tubule. In the type 2 diabetes model rat with normoalbuminuria (by feeding high fat-diet wihtin 4 weeks), apo A-I were not detected in urine.
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| Free Research Field |
糖尿病性腎症
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