2014 Fiscal Year Final Research Report
Mechanisms of noradrenaline-mediated modulation of synaptic plasticity in the nociceptive amygdala
| Project/Area Number |
25860429
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 情動 / 慢性痛 / シナプス可塑性 / 扁桃体 / 電気生理学 |
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| Outline of Final Research Achievements |
I have found the followings: first, noradrenaline applied to the acute brain slices containing the central amygdala potently modulated the synaptic transmission. Second, injection of anti-dopamine beta-hydroxylase-saporin into the central amygdala, which resulted in destroying of the noradrenergic fibers in the amygdala, changed in spontaneous pain-related behaviors and the thermal preference. Finally, I have established a system for Cre recombinase-dependent expression of channelrhodopsin in the noradrenergic neurons that would enable light-triggered release of intrinsic noradrenaline in vivo and ex vivo preparations.
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| Free Research Field |
神経科学
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