In vivo patch-clamp analysis of itch transmission in central nerve system

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860431
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pain science
• Research Institution: University of Toyama (2014); National Institute for Physiological Sciences (2013)
• Principal Investigator: UTA Daisuke 富山大学, 大学院医学薬学研究部(薬学), 助教 (70598416)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 痒み / 脊髄後角 / in vivoパッチクランプ / 5-ＨＴ / 痛み / 大脳皮質 / シナプス伝達 / 中枢神経

Outline of Final Research Achievements

The mechanism for the itch transmission in the central nervous system remains unclear. The present study was designed to analyze pruritic synaptic responses evoked in spinal dorsal horn and cortex neurons of rodents by using an in vivo whole-cell patch-clamp and extracellular recording technique. The present main finding is that subpopulation of spinal dorsal horn and cortex neurons are responsible for pruritic cutaneous 5-HT stimulation.

Free Research Field

神経生理学