Impact of NA activity on the properties of influenza virus

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860476
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Osaka Prefectural Institute of Public Health
• Principal Investigator: HIROI SATOSHI 大阪府立公衆衛生研究所, その他部局等, 主任研究員 (40455548)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: インフルエンザウイルス / HA / NA

Outline of Final Research Achievements

To evaluate effect of NA activity on the properties of influenza A H1N1pdm viruses, a total of 40 isolated strains including three oseltamivir resistant strains were analyzed. The results showed that the strains have different NA activities, and all oseltamivir resistant strains with H275Y mutation in the NA have lower activity than H275 strains. Phylogenetic analysis of NA gene showed that NA activity of oseltamivir sensitive strains was not correlated with specific mutation, and NA activity did not have obvious impact on replication ability of the strains. The functional significance of the NA activity of oseltamivir resistant strains should be further investigated.

Free Research Field

ウイルス学