2015 Fiscal Year Final Research Report
Elucidation of transcription factory that is associated with the transcriptional regulation of the ABO gene.
| Project/Area Number |
25860486
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ABO / 血液型 / 血液型亜型 / 転写調節 |
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| Outline of Final Research Achievements |
1) We identified novel genetic mutation responsible for the blood group subtype Am, and clarified association of transcriptional factor RUNX1. 2) We identified novel genetic mutations responsible for the blood group subtype A3 or B3. 3) We identified candidate regions that possess potential enhancer activity for the ABO expression. 4) It was clarified that the transcription of the ABO gene is regulated by epigenetic mechanism, and some reagent could alter the expression level of ABO.
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| Free Research Field |
法医学
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