The effect of Go-sya-jinki-Gan about improving insulin resistance in senescence accelerating mice, SAMP8

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860499
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Yamaguchi University
• Principal Investigator: KAGAWA Syota 山口大学, 医学部, 助教 (30463201)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 医食同源 / 漢方医学 / 老年医学 / 代謝学 / 脂質 / 褐色脂肪 / 糖尿病

Outline of Final Research Achievements

This grant could give us two results. One of the result is that Japanese kampo medicine, ‘Go-sha-jinki-Gan’, prevented insulin resistance in skeletal muscle of aging model, SAMP8. These data also expressed that sarcopenia was occurred in aging skeletal muscle and Go-sha-jinki-Gan could stop to accelerate sarcopenia via improving skeletal muscle insulin/IGF1 signaling. Another of the result is low carbohydrate diet could initiate to make brown adipose tissue hyper-function and white adipose tissue ‘browning’ in terms of ‘food oriented medicine’. Low carbohydrate diet upregulated energy expenditure in aging model, SAMP8 via fat oriented energy utility but not sugar oriented energy utility. However, low carbohydrate diet up to aging was deteriorated skeletal muscle atrophy.
These result were the first evidence and the former was accepted to ‘Phytomedicine’ Journal in 2015.

Free Research Field

東洋医学