Application to cancer immunotherapy of natural compounds regulating macrophage activation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860501
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kumamoto University
• Principal Investigator: Fujiwara Yukio 熊本大学, 大学院生命科学研究部, 講師 (70452886)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 代替医療 / ガン / マクロファージ

Outline of Final Research Achievements

It is well known that tumor-associated macrophages play an important role in tumor progression. In this study, we identified several natural compounds (corosolic acid, oleanolic acid and soyasapogenol etc.) as candidate compounds regulating macrophage activation and those compounds suppressed tumor proliferation under co-culture with macrophages and tumor cells. Furthermore, oral administration of those compounds significantly suppressed both tumor development and metastasis in a tumor-bearing mice. Therefore, these compounds may be potentially new tool for tumor prevention and therapy.

Free Research Field

医歯薬学