2015 Fiscal Year Final Research Report
Development of a novel treatment with fetal membrane-derived mesenchymal stem cells to inflammatory bowel disesase
| Project/Area Number |
25860515
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 炎症性腸疾患 / 間葉系幹細胞 |
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| Outline of Final Research Achievements |
Mesenchymal stem cells (MSCs) have been reported to be a valuable cell source in cell therapy, and bone marrow (BM) represents a major source of MSCs; however, there are several limitations when using BM-MSCs, including inadequate cell numbers, invasiveness and donor site morbidity. Recently, several studies have shown that MSCs can be easily isolated from human fetal membrane (FM), and a large amount of cells can be obtained. We thus examined the therapeutic effects of transplantation of human FM-derived MSCs (hFM-MSCs) in dextran sulfate sodium (DSS)-induced colitis in rats.
Transplantation of hFM-MSCs provided significant improvement in a rat model of severe colitis, possibly through inhibition of monocyte/macrophage activity. FM-MSC would be considered as a new cell source for the treatment of severe colitis.
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| Free Research Field |
消化器病学
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