2015 Fiscal Year Final Research Report
Researching that global repression of miRNA function may cause inflammation-associated gastric and hepatic tumorigenesis
| Project/Area Number |
25860520
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | microRNA / 炎症性発癌 |
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| Outline of Final Research Achievements |
I am researching "chronic impairment of microRNA function due to chronic inflammation may cause inflammation-associated tumorigenesis" and "preventing
inflammation-associated tumorigenesis". I published that ROCK inhibitor enhanced remaining miRNA function by promoting miRNA-mediated mRNA decay. And I am submitting the paper that global impairment of miRNA function in chronic inflammation may have a causal role in inflammation-associated colonic oncogenesis, and enhancement of miRNA function is a potential method for preventing colonic inflammation-associated tumorigenesis. This time I researched gastric and hepatic inflammation-associated tumorigenesis, but enhancement of miRNA function did not prevent inflammation-associated tumorigenesis of stomach and liver. Hereafter I will research molecular mechanism that global impairment of miRNA function contribute to inflammation-associated oncogenesis.
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| Free Research Field |
病態医化学
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