2014 Fiscal Year Final Research Report
Analyzing mechanism of Hepatitis C Virus eradication by Interferon-lambda
| Project/Area Number |
25860523
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | C型肝炎ウイルス / MHC Class I |
|---|
| Outline of Final Research Achievements |
For this study, we could not confirm induction of ISG expression by IFN- λ as we expected. Therefore, we tried to explore other possibility.
MHC Class I is a molecule that is known to support eradication of viruses. When cells are infected by viruses, part of virus protein is carried by MHC Class I to the surface of infected cells. Cytotoxic T cells recognize these protein conjugated MHC Class I molecules and attack these cells. As a result, viruses infecting these cells are eliminated with cells from host's body. For HCV, after infection or adding IFN-α, induction of MHC Class I expression was also confirmed (Kang et al, 2014). Therefore we planned to evaluate the results after adding IFN-λ, and found MHC Class I induction. From these results it was suggested that IFN-λ may also affect in the same mechanism as IFN-α.
|
| Free Research Field |
C型肝炎ウイルス
|
