Impacts of protein tyrosine phosphatase Shp2 on liver inflammation

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860526
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Kanazawa University
• Principal Investigator: NAGATA Naoto 金沢大学, 脳・肝インターフェースメディシン研究センター, 特任助教 (70456408)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: チロシンフォスファターゼ / 脂肪肝炎 / 過栄養

Outline of Final Research Achievements

Recently, non-alcoholic steatohepatitis has been rapidly increasing due to a high-fat diet and/or lack of exercise. Aim of this study is to investigate the role of Src homology phosphatase 2 (Shp2) in regulation of lipid metabolism and inflammation in the liver of mice model of NASH.
This study revealed that liver-specific deficiency of Shp2 reduced lipid accumulation and inflammation in the liver of mice fed CDAA diet. I also found that Shp2 inhibitor partially improved CDAA diet-induced NASH. Taken together, Shp2 might be a novel molecular target of NASH.

Free Research Field

肝臓学