2014 Fiscal Year Final Research Report
Wnt signaling in pancreatic periacinar myofibroblasts in response to inflammatory and fibrotic mediators
| Project/Area Number |
25860531
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
INATOMI OSAMU 滋賀医科大学, 医学部, 助教 (70530351)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | 膵線維化 / 筋線維芽細胞 / Wnt |
|---|
| Outline of Final Research Achievements |
This study was designed to investigate the mechanism of pancreatic fibrogenesis via Wnt signaling in pancreatic myofibroblasts (activated stellate cells). Microarray assay showed that IL-1 stimulation induced the mRNA level of wnt2, 5a, and RUNX. On the other hands, TGF-β stimulation induced the mRNA level of Wnt 4, 9,11. Wnt 4 and 5a expression were significantly increased in the mild fibrotic area in the cerulean-induced chronic pancreatitis model mice. These findings suggest that Wnt signaling may be involved in pancreatic fibrogenesis in response to various inflammatory and fibrotic mediators.
|
| Free Research Field |
膵
|
