The investigation of pathophysiology of inflammatory bowel disease with induced pluripotent stem cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860532
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: The Tazuke Kofukai (2015); Kyoto University (2013-2014)
• Principal Investigator: YOSHINO Takuya 公益財団法人田附興風会, 医学研究所 第4研究部, 研究員 (10588875)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 炎症性腸疾患 / iPS細胞 / マクロファージ / エピゲノム

Outline of Final Research Achievements

Epigenetics would play an imporatant role in the etiology of inflammatory bowel disease (IBD). Therefore, we evaluate the function and DNA-methylation of macrophages derived from iPS cells comparing with those of intestinal macrophages.
iPS cells derived from patients with IBD could be established, although the accumulation of sufficient case has been difficult. We found several candidate gene by evaluating DNA-methylation analysis between macrophage dereived from iPS cells and intestinal macrophages. At present, we are working on accumulation of further cases and functional analysis of these genes.

Free Research Field

医歯薬学