Pharmacogenetics for IBD drug

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860539
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Urabe Yuji 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 客員研究員 (10648033)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: SNP / IBD / Pharmacogenetics / drug

Outline of Final Research Achievements

Recently, the development of various new drugs for inflammatory bowel disease (IBD) has improved the rate of remission maintenance. Nevertheless, the methods for remission maintenance and/or permanent treatment for IBD are complicated according to the various types of IBD treatments available. The aim of this study was to clarify the genetic factors contributing to the treatment effect for IBD. Genomic DNA was extracted from approximately 600 IBD patients, and the single nucleotide polymorphisms (SNPs) of genes associated with the treatment effect of IBD drugs were determined using a multiplex polymerase chain reaction-based invader assay. We explored susceptibility genes for the effects of IBD drugs; however, did not discover any significant association of the SNPs tested with the effect of IBD drugs.

Free Research Field

Genetics Gastroenterology