2014 Fiscal Year Final Research Report
Association between the lipotoxicity of saturated fatty acids in the liver and pathophysiology of NASH.
| Project/Area Number |
25860551
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Yokohama City University |
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Principal Investigator |
OGAWA Yuji 横浜市立大学, 附属病院, 指導診療医 (20644959)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 非アルコール性脂肪肝疾患 / 非アルコール性脂肪肝炎 / 飽和脂肪酸 / lipotoxicity |
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| Outline of Final Research Achievements |
The right jugular veins of C57BL/6 mice were catheterized. Then the mice were continuously infused with ethyl palmitate. Short-term palmitate treatment recruited neutrophil and macrophage to the liver, and activated hepatic stellate cell. Long-term palmitate treatment induced liver fibrosis. We showed that the saturated fatty acid, palmitate, induces nonalcoholic steatohepatitis(NASH)-like condition. The molecular interactions in this study could provide novel therapeutic targets for the treatment of NASH.
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| Free Research Field |
非アルコール性脂肪肝炎
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