2016 Fiscal Year Final Research Report
The mechanisms of chemoresistance induced by amphiregulin nuclear translocation
| Project/Area Number |
25860552
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Research Collaborator |
Yun Chris Emory University School of Medicine, Division of Digestive Diseases
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 消化器癌 / シグナル伝達 |
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| Outline of Final Research Achievements |
We identified two promising factors, Lysophosphatidic acid receptor 2 (LPA) and Na+/H+ exchange regulatory factor 2 (NHERF2) which have some funcions to regulate AR and induce chemoresistance. However, the analysis with clinical samples showed that AR expression did not contribute poor prognosis and the additional laboratory investigation was not able to detect AR nuclear translocation in pancreatic cancer cell lines, which required the revision of our initial study design. We focused on LPA2 and NHERF2 as the oncogenic and chemoresistant factor in colon cancer, instead of pancreatic cancer. We kept experiments and got data which showed LPA2 and NHERF2 had specific functions in terms of carciogenesis and chemoresistance. In addition, we performed SNPs and IHC analysis in pancreatic cancer patients and found p53 and MDM2 as specific biomarkers.
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| Free Research Field |
消化器癌
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