2014 Fiscal Year Final Research Report
The mechanisms of intestinal fibrosis and strictures associated with upregulation of NADPH oxidase 4 and reactive oxygen species
| Project/Area Number |
25860553
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
INOUE Ken 京都府立医科大学, 医学(系)研究科(研究院), 特任助教 (10613945)
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| Research Collaborator |
NAITO Yuji 京都府立医科大学, 消化器内科, 准教授
KISHIMOTO Shunsuke 京都府立医科大学, 消化器内科
HOTTA Yuma 京都府立医科大学, 消化器内科
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 消化管線維化 / 消化管狭窄 / 筋繊維芽細胞 / Nox4 |
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| Outline of Final Research Achievements |
In mouse myofibroblast isolated from (C57BL/6), LmcMF and SmcMF, TGFβ1 administration induced higher expression of Nox4 and pro-collagen 1. Pretreatment of these cells with TGFβ inhibitor and Nox4 siRNA significantly inhibited pro-collagen 1 expression.
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| Free Research Field |
消化器内科
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