2014 Fiscal Year Research-status Report
非アルコール性脂肪性肝炎の病態形成におけるサイトグロビンの関与
| Project/Area Number |
25860554
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| Research Institution | Osaka City University |
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Principal Investigator |
LE THUY 大阪市立大学, 医学(系)研究科(研究院), 助教 (10572175)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 遺伝子 |
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| Outline of Annual Research Achievements |
In this study, we found that CYGB deficiency promotes liver fibrosis and cancer development in a non-alcoholic steatohepatitis model in mice via activation of oxidative stress pathway (Am J Pathol 2015;185:1045-60). Therefore, the absence of CYGB likely promotes both fibrotic and carcinogenic process in chronic liver disease. CYGB which presences on HSCs and suppresses their activation should be considered primary target for the development of new antifibrotic therapies.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
Liver fibrosis and cirrhosis accounts for up to 45% of death in developed countries, while we still lack effective antifibrotic therapies.We previously showed that Cygb-deficient mice exhibit susceptibility to cancer development in the liver and lung with diethylnitrosamine administration.Furthermore, in this study, we found that CYGB deficiency promotes liver fibrosis and cancer development in a non-alcoholic steatohepatitis model in mice via activation of oxidative stress pathway.Therefore, the absence of CYGB likely promotes both fibrotic and carcinogenic process in chronic liver disease.The important concern should be the protective role of CYGB in liver fibrosis development. CYGB which presences on HSCs and suppresses their activation should be considered primary target for the development of new antifibrotic therapies.
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| Strategy for Future Research Activity |
Explore the mechanism action of CYGB in preventing liver fibrosis and cancer development. Recombinant human CYGB protein will be produced and examined its antifibrotic activity. Animal model of alcoholic induced liver diseases will be established.
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| Causes of Carryover |
謝金の支払いが不要となったため。
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| Expenditure Plan for Carryover Budget |
物品購入に使用する予定である。
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[Journal Article] Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.2015
Author(s)
Thuy le TT,Matsumoto Y,Thuy Tuong TV, Hai H,Suoh M,Urahara Y,Motoyama H,Fujii H,Tamori A,Kubo S,Takemura S,Morita T,Yoshizato K, and Kawada N.
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Journal Title
Am J Pathol.
Volume: 185
Pages: 1045-1060
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[Journal Article] (1)Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver.2014
Author(s)
Motoyama H, Komiya T, Thuy le TT, Tamori A, Enomoto M, Morikawa H, Iwai S, Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Murakami Y, Yoshizato K, Kawada N.
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Journal Title
Lab Invest.
Volume: 94
Pages: 192-207
DOI
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[Journal Article] Relationship between inosine triphosphate genotype and outcome of extended therapy in hepatitis C virus patients with a late viral response to pegylated-interferon and ribavirin.2014
Author(s)
Hai H, Tamori A, Enomoto M, Morikawa H, Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Thuy le TT, Tanaka Y, Kawada N.
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Journal Title
J Gastroenterol Hepatol.
Volume: 29
Pages: 201-207
DOI
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