Molecular analysis of S100A8 protein and development of new treatment for metabolic syndrome and cardiovascular disease

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860587
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Hasumi Eriko 東京大学, 医学部附属病院, 助教 (70599547)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: S100A8 / アディポカイン / メタボリックシンドローム / 脂肪組織炎症

Outline of Final Research Achievements

Previous basic and clinical studies have shown that inflammation plays an essential role in metabolic diseases as well as atherosclerosis. However, it is still unclear how inflammation is initiated in obese adipose tissue. We found that expression of S100A8 increased in obese adipose tissues. It indicated that S100A8 play a important role for inflammation in adipose tissue. Since, we created S100A8 knockout mice to investigate the role of S100A8 in obese tissue. S100A8 knockout mice showed lower insulin sensitivity relative to foxed mice. This result suggested that S100A8 have a possibility of improving glucose homeostasis.

Free Research Field

循環器内科