Pathophysiological significance of cathepsin K in dilated cardiomyopathy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25860594
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Nagoya University
• Principal Investigator: Okumura Takahiro 名古屋大学, 医学部附属病院, 助教 (60635598)
• Research Collaborator: MUROHARA TOYOAKI 名古屋大学, 医学系研究科, 教授 (90299503) ; BANDO YASUKO 名古屋大学, 医学部附属病院, 講師 (60452190) ; MORIMOTO RYOTA 名古屋大学, 医学系研究科, 寄附講座助教 (00755499)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 拡張型心筋症 / カテプシン

Outline of Final Research Achievements

To clarify the pathophysiological role of cathepsin K, we investigated the association between the expression of cathepsin K and pathophysiological index, clinical imaging data, or prognosis in patients with dilated cardiomyopathy (DCM). The results of our studies were as follows; 1) Myocardial fibrosis and impaired left ventricular (LV) relaxation is more serious in late gadolinium enhancement positive group. Unfortunately, the expression of cathepsin K was not associated with the extent of fibrosis. 2) LV phase entropy using 99mTc-sestamibi gated myocardial perfusion SPECT, which may reflect impairment of Ca2+-handling caused by decreased SERCA2a mRNA levels, is a novel prognostic predictor of adverse cardiac events in patients with DCM with a narrow QRS complex. 3) The combined reduction of campesterol and lathosterol that indicated intestinal cholesterol absorption and liver synthesis predicts future cardiac events in patients with early-stage DCM.

Free Research Field

医歯薬学