2014 Fiscal Year Final Research Report
Investigation of the role of regulatory T cells in atherosclerotic disease
| Project/Area Number |
25860601
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kobe University |
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Principal Investigator |
SASAKI NAOTO 神戸大学, 医学(系)研究科(研究院), 助教 (00514746)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 動脈硬化症 / 炎症 / 免疫細胞 |
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| Outline of Final Research Achievements |
We provided direct evidence that regulatory T cells (Tregs) prevent atherosclerotic disease by dampening pathogenic immune responses. We also demonstrated that promotion of an endogenous regulatory immune response could be a possible therapeutic approach to prevent the development of atherosclerosis and abdominal aortic aneurysm and induce regression of established atherosclerosis in mice.
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| Free Research Field |
医歯薬学
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