Metabolomics in heart failure

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860602
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kobe University
• Principal Investigator: TANAKA Hidekazu 神戸大学, 医学(系)研究科(研究院), 講師 (20590342)
• Research Collaborator: TOH Ryuji 神戸大学, 医学研究科, 特命准教授 (50379418) ; HIRATA Ken-ichi 神戸大学, 医学研究科, 教授 (20283880)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 心不全 / メタボローム解析 / 2-アミノ酪酸 / グルタチオン / 酸化ストレス

Outline of Final Research Achievements

Heart failure is a major cause of morbidity and mortality worldwide. However, conventional biomarkers are insufficient to detect early stage of HF and identification of more sensitive markers is an urgent task. We conducted the comprehensive quantification of water-soluble metabolites in blood of atrial septal defect (ASD) patients using a gas chromatograph-mass spectrometry. We found the mean level of 2-Aminobutyric acid (2-AB) in ASD patients was significantly higher than that in healthy volunteers, and 1 month after transcatherter closure of ASD, serum 2-AB levels in patients decreased to almost the same levels as healthy volunteers. We revealed that 2-AB was produced as the byproduct of GSH synthesis reactions. We also demonstrated that oxidative stress lead to 2-AB production. 2-AB monitoring may facilitate the early diagnosis strategy for heart failure.

Free Research Field

医歯薬学