2015 Fiscal Year Final Research Report
The impact of plasma heparin cofactor II activity in patients with aortic aortic aneurysm
| Project/Area Number |
25860605
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ISE Takayuki 徳島大学, 大学病院, 助教 (90621649)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 大動脈瘤 |
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| Outline of Final Research Achievements |
Progression of aortic aneurysms often cause fatal events such as rupture and dissection.Thrombin has a crucial role in vascular remodelig through protease-activated receptor-1 activation in cardiac fibroblasts and cardiomyocytes. As heparin cofactor II (HCII) inhibits the action of tissue thrombin in the cardiovascular system, it is possible that HCII counteracts the development of vascular remodeling.We investigated the relationships between plasma HCII activity and presence of vascular disease, including aortic aneurusm, peripheral artery disease, coronary artery disease and cerebral artery disease.Plasma HCII activity was inversely associated with morbidity of vascular disease, including aortic aneurysm, peripheral artery disease, coronary artery disease and cerebral artery disease. This finding suggests that tissue thrombin inactivation by HCII is a novel therapeutic target for vascular remodeling and atherosclerosis.
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| Free Research Field |
循環器
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