2015 Fiscal Year Final Research Report
Long non coding RANs regulate the cardiac lineage during embryonic stem cell differentiation
| Project/Area Number |
25860621
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | long non coding RNA |
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| Outline of Final Research Achievements |
Long non coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides, but they do not code proteins. LncRNAs constitute a heterogenic class of RNAs that includes intergenic RNAs, antisense transcripts, and enhancer RNAs. In recent, several studies have been reported that lncRNAs required for cardiac development and disease. It is obvious that many lncRNAs are expressed in cardiac development and are necessary for cardiovascular lineage. However, it has not been investigated in detail how lncRNAs are regulated in cardiac development and heart failure.Using embryonic stem cell (ESC) differentiation strategies, lncRNAs which restricted to cardiac cell were analyzed. In this study, to establish a map of lncRNAs expression and potential target gene networks during ESC differentiation. We identified the potential target genes of these lncRNAs through a bioinformatic correlation network that clusters lncRNAs into specific functional pathway.
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| Free Research Field |
循環器内科
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