2014 Fiscal Year Final Research Report
Effects of atrial epicardial adipose tissue on electrical and structural remodeling on atrial fibrillation
| Project/Area Number |
25860626
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 心房細動 / 心房周囲脂肪 / 高脂肪食 / 電気的リモデリング / カテーテルアブレーション |
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| Outline of Final Research Achievements |
In obese pigs which fed a high-fat diet, pulmonary vein electrical refractory periods were significantly shorter and atrial fibrillation lasted longer than in the control group, which fed a normal diet. However, no histopathologic characteristics differed between the groups. These data suggests that the shorter pulmonary vein electrical refractory periods observed in response to the high-fat diet increased vulnerability to atrial fibrillation, and these electrophysiologic characteristics may underlie obesity-related atrial fibrillation. We also elucidated that left atrial ablation guided by 3-dimensional reconstructed epicardial adipose tissue CT image following pulmonary vein isolation provided a favorable clinical outcome after ablation in patients with persistent atrial fibrillation. This suggested that epicardial adipose tissue had potentially involved a vulnerable substrate for atrial fibrillation.
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| Free Research Field |
医歯薬学
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