Early Detection of Myocardial Damage with Cardiac Magnetic Resonance Imaging in Patients with Extracardic Sarcoidosis

2014 Fiscal Year Final Research Report

• Project/Area Number: 25860630
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: NAGAI Toshiyuki 独立行政法人国立循環器病研究センター, 病院, 医師 (00528218)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 心臓サルコイドーシス / 早期診断

Outline of Final Research Achievements

Approximately 13% of extracardiac sarcoidosis patients without cardiac manifestation had myocardial damage defined by late gadollinuum enhancement cardiac magnetic resonance imaging (LGE-CMR), however, this small myocardial damage might not be associated with worse clinical outcomes (Chest 2014; 146: 1064). Futhermore, in additional retrospective analyses, the long-term effect of corticosteroid therapy (Circ J 2015, in press) and the prognostic significance of basal interventricular thinning (Circ J 2015, in press) have also been clarified. These findings will provide the key data for establishment of diagnostic and treatment guidelines in patients with sarcoidosis.

Free Research Field

循環器内科学