2014 Fiscal Year Final Research Report
Intracellular signal analysis of M-CSF-induced lymphangiogenesis stimulating factor VEGF-C,-D production
| Project/Area Number |
25860633
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Tatsuma 東北大学, 大学病院, 助教 (40396479)
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| Research Collaborator |
NIHEI Mayumi 東北大学, 大学院医学系研究科
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | MCSF / VEGF-C / VEGF-D / リンパ管新生 |
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| Outline of Final Research Achievements |
Lymphangiogenesis occurs in binding to VEGFR3 mainly expressed in lymphatic vessels of their ligand,VEGF-C or VEGF-D. It has been reported that macrophages and skeletal muscle is source of VEGF-C,-D production. In the present study, we examined wheather M-CSF induce the VECF-C,-D production. VEGF-C, D production induced from mouse macrophages was not observed by administration M-CSF. But in skeletal muscle, diaphragm, and myocardium, we confirmed that the expression levels of VEGF-C,-D were significantly higher.
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| Free Research Field |
リンパ管新生
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